hrp0086p1-p238 | Diabetes P1 | ESPE2016

Correction of Carnitine Deficiency in Children with Recent Onset Type 1 Diabetes

Castell Anne Laure , Bibal Cecile , Gaignard Pauline , De Filippo Gianpaolo , Bougneres Pierre

Background: Carnitine deficiency (CD) has been reported in children at time of type 1 diabetes (T1D) diagnosis. By impairing free fatty acid ß-oxidation in liver, muscle mass and pancreatic ß cells, CD might impair glucose homeostasis and residual insulin secretion. We postulate that reversed of these FAO defects may help regenerate a healthier ß cell mass and increased the diabetes honeymoon duration.Objective: Evaluate the effects of car...